LONDON: A new finding by scientists showing how the immune system
reduces cholesterol levels could lead to heart pills as good as statins
without its potentially dangerous side-effects. A discovery by British
scientists could lead to improved and new heart-protecting treatments.
A new cholesterol-busting pill without the potentially dangerous side
effects of statins could become reality thanks to a major breakthrough
by British scientists.
Scientists at the University of Edinburgh have found that cholesterol
levels are suppressed by the body's immune system as part of the process
that fights off viral infections, the Daily Express reported.
"We have identified the immune hormone that does this. Statins are
effective but crude drugs," Professor Peter Ghazal, leader of the
research team, said.
"This discovery gives the ability to be a little more refined and by
being a lot more subtle in how to control the production of cholesterol
you can prevent a lot of these adverse side-effects," he noted.
Professor Ghazal hopes drugs to mimic the hormone that are just as
effective as statins without their side effects may be an estimated five
years away.
Statins have been hailed as a wonder drug for reducing the harmful blood
fat that furs up arteries triggering tens of thousands of heart attacks
and strokes that kill 150,000 people every year in Britain.
But there is evidence that some of the seven million people who take the
daily heart pills can suffer side effects ranging from muscle aches and
tummy upsets to a rare but serious lung disorder, as well as diabetes.
And for about one in four people statins do not reduce their cholesterol
to a safe level because they do not work or patients cut the dose or
stop taking them.
Yet experts believe the benefits of taking the tablets, that can cost as little as 4p a day, far outweigh any potential risks.
The new study is published in the journal Biochimie.
what is statins ?
Statins (or
HMG-CoA reductase inhibitors) are a class of drugs used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver. Increased cholesterol levels have been associated with cardiovascular diseases,
and statins are therefore used in the prevention of these diseases. Research has found that statins are most effective for treating cardiovascular disease (secondary prevention), with questionable benefit in those without previous CVD but with elevated cholesterol levels.
Statins have rare but severe adverse effects, particularly muscle damage, and some doctors believe they are overprescribed.
The best-selling statin is
atorvastatin, marketed as Lipitor (manufactured by Pfizer) and Torvast. By 2003 atorvastatin became the best-selling pharmaceutical in history,
with Pfizer reporting sales of US$12.4 billion in 2008.
As of 2010, a number of
statins are on the market:
atorvastatin (Lipitor and Torvast),
fluvastatin (Lescol), lovastatin (Mevacor, Altocor, Altoprev), pitavastatin (Livalo, Pitava), pravastatin (Pravachol, Selektine, Lipostat), rosuvastatin (Crestor) and simvastatin (Zocor, Lipex). Several combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available.
1 comment:
Is it true? Is out in the market today? How true that this doesn't have side effects like statins? Does it have enough evidence?
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